Medicinal herbs have been used by humans for a long time without any proof of their toxicity. The goal of this study was to determine the toxicity profile of . Standard procedures were used to conduct phytochemical screening of methanol leaves extract. The limit dose test was used to determine acute oral toxicity (LD50), whereas graded doses (150, 300, 600, and 1200mg/kg) were given daily for 28 days in the sub-chronic toxicity research. The presence of flavonoids, saponins, anthraquinones, phlobatanins, alkaloids, and tannins was discovered in . The (LD50) of methanol leaf extract (PSMLE) was determined to be larger than 3000mg/kg body weight, and there was no fatality up to 14 days of observation. PSMLE (150-1200mg/kg) treatment resulted in a substantial reduction (p
Key words: Acute oral toxicity (LD50), Phytochemicals, Pistia stratiole, Sub-chronic.
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