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Review Article

Dusunen Adam. 2010; 23(4): 275-281

Pathophysiology of clozapine induced sialorrhea and current treatmant choices

Sema Yeşilyurt, İmer Aras, Kürşat Altınbaş, Murat İlhan Atagün, Erhan Kurt.


Clozapine has been used for approximately 40 years and it is still the gold standard for treatment resistant schizophrenia even though it may cause considerable side effects. One of the common side effects during the treatment with clozapine is sialorrhea. Although clozapine has anticholinergic side effects, pathogenesis of sialorrhea is still unclear. Despite sialorrhea is quite common and might influence quality of life, treatment choices and their efficacy for this side effect is limited. Thus, in this article, pathophysiology and treatment of clozapin induced sialorrhea is reviewed.

Key words: Clozapine, sialorrhea, pathophysiology, treatment choices

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