Introduction: Histopathologic analysis of tissue samples is crucial for the management of patient with brain mass lesions. Lesion localization and interaction with adjacent normal tissue can be easily provided with modern imaging techniques. On the other hand, they are insufficient to reveal histopathologic nature of lesions. Stereotactic techniques can provide diagnostic tissue samples from lesions safely and sensitively. We aimed to discuss our experience and results with the help of the literature. Method: Overall, 106 stereotactic brain biopsy procedure were performed on 100 patients in our clinic from 1995 to 2010. Lesion locations, histopathological results, diagnostic yield, morbidity and mortality were reviewed. Results: This study included 64 males and 36 females aged 9 to 81 years (mean: 53 years). Lesion localizations were classified as: frontal 21, temporal 11, parietal 14, occipital 7, deep-seated 12, suprasellar 2, cerebellum 1 and 32 patients had multiple lesions. Histopathological diagnosis were as follows: neuroepithelial tumors 51, metastases 31, infectious 7, gliozis 8, demyelinization 1. The diagnostic yield was %90. Conclusions: Histopathologic confirmation of brain mass lesions is the main method to decide management. Although new imaging techniques provide detailed data, evaluating tissue sampling is still the gold standart in determining the histopatologic diagnosis. Stereotactic- CT guided brain biopsy is a safe, reliable method of obtaining tissue sample with high accuracy.
Key words: Sterotactic biopsy, brain, histopathology
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