Abstract

Structural abnormalities are one of the most important issues in schizophrenia etiopathogenesis. Corpus callosum which is the biggest and most important interhemispheric pathway in the brain is often mentioned in structural abnormalities in schizophrenia. These psychotic disorders share some common features: Positive symptomatology dominates the clinical picture, there is lack of EEG pathology, borderline IQ level, lack of connection test findings and associated structural brain deformities. In this case report the relationship between this rare cerebral structural abnormality, corpus callosum agenesis and schizophrenia is discussed. It is not possible to establish a causal relationship between such structural abnormalities and psychosis. Nevertheless in some group of schizophrenic patients, they may play an important role in etiology.

Key words: Corpus callosum, schizophrenia, midline brain abnormalities