Pressure Sensitive Adhesive (PSA) is a type of adhesive generally made from viscoelastic, sticky polymer chains, making it widely used as pads and ultra-thin coatings in medical applications. Some types of PSA materials are popular, one of which is silicon-based materials. Silicone is the commercial name for many silicon-based products. Technically, silicone (polysiloxane) is a polymer with the chemical formula [R2SiO]n, in which R can be any organic groups including methyl, phenyl, alkenyl, and hydrogen. Silicone PSA is increasingly used in medical applications such as in drug delivery systems in the form of transdermal patches. Silicone PSA offers excellent solubility and permeability for lipophilic drugs, but in some cases, it can be used in hydrophilic drugs. The use of PSA has proved to have some effects on transdermal patch preparations in accordance with the shape, design, and base used. Several studies indicate that PSA transdermal patches have such benefits as being able to control drug release both in vitro and in vivo, maintain the stability of a preparation and active substance, and provide the same effectiveness as that of a patch with other mechanisms.
Key words: PSA (Pressure Sensitive Adhesive), Silicone, Polydimethylsiloxane (PDMS), Transdermal Patch
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