Activated protein C resistance in women using second generation oral contraceptives
Namra Mahmood.
Abstract
Objective: To observe the effect of Combined oral contraceptive pills (COCPs) on activated protein C (APC) resistance after three months of its use and mean change from baseline and was stratified according to age groups and parity.
Methodology: This cross-sectional prospective descriptive study was conducted in Department of Pathology, Post Graduate Medical Institute, Lahore from 1/03/2018 to 02/03/2019. It included 54 female patients aged between 18-45 years who were scheduled by the family planning clinic of Lahore General Hospital, Lahore to start second generation oral contraceptive pills (OCP). Blood samples were collected and activated protein C resistance was assessed before the start of OCP and then after 3 months of onset of contraceptive use.
Results: Mean age of women was 29.5±5.3 years. The parity ranged from 1 to 6 (mean 3.06±1.20). APC resistance increased significantly as seen from a decrease in PCAT/PCAT-0 ratio with a mean change of 0.39±0.23 (p
Key words: Oral Contraceptives, hormonal contraceptives, APC Resistance, Activated Protein C Resistance, Protein C, hypercoagulable state, hypercoagulability, thrombosis, deep vein thrombosis.
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