DETECTION OF NEUROTOXINS BMAA AND DAB INCULTURED CYANOBACTERIAL ISOLATE SYNECHOCYSTIS NPLB 2 USING LC/ESI-MSn
Umar A. Aminu and Isah M. Fakai.
Abstract
The non-protein amino acid β-N-methylamino-L-alanine (BMAA) has been associated to the development of a number of neurodegenerative diseases in humans including amyotrophic lateral sclerosis (ALS), Alzheimers disease, and Parkinsons disease. A range
of cyanobacteria, diatoms, and dinoflagellates that are found in freshwater, saltwater, and terrestrial ecosystems have all been reported to produce BMAA. Axenic laboratory culture of Synechocystis NPLB 2 strain was analysed by high performance liquid chromatographyelectrospray ionization ion trap mass spectrometry. Derivatized BMAA and its structural isomer 2,4-diaminobutyric acid (2,4-DAB) were detected in Synechocystis NPLB 2 strain of cyanobacteria. The presence of these toxins in waters used for various human needs raises concerns for public health.
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