Grewia crenata is a plant with acclaimed analgesic and anti-inflammatory properties amongst traditional bone setters in north- west, Nigeria. Hydromethanolic extract of Grewia crenata leaf (GCL) was assessed for its anti-inflammatory activity. Invitro anti-inflammatory activity was evaluated using membrane stabilization tests (heat and hypotonicityinduced hemolysis) and protein denaturation assay while the in vivo anti-inflammatory activity was accessed using eggalbumin- induced oedema model in albino rats.The results showed that GCL at a concentration range of 50 400 μg/ml significantly (p0.05) compared to Diclofenac sodium. However, the effect of the extract on hypotonicity-induced hemolysis was significantly increased (p
Key words: Anti-inflammatory activity, Grewia crenata, HRBC membrane, Hemolysis,Oedema
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