High fat diet is one of the leading causative factors for high cholesterol levels. Hyperlipidemia plays a major role in the development of atherosclerosis and oxidative stress. Aim & Objective: The current study was taken to assess the high fat diet changes in the body weight, hepatic and renal tissue treated with the various doses of aqueous extracts of Phyllanthus emblica fruit and Terminalia arjuna bark. Materials and Methods: Group I served as normal control. Group II was fed with high fat diet. Group III was fed with high fat diet and aqueous extract of Phyllanthus emblica fruit -200 mg/kg body wt. Group IV was fed with high fat diet and aqueous extract of Phyllanthus emblica fruit -400 mg/kg body wt. Group V was fed with high fat diet and aqueous extract of Terminalia arjuna bark -400mg/kg body wt. Group VI was fed with hyperlipidemic diet + Atorvastatin standard drug. Results: Histopathological analysis using hematoxylin and eosin stain for liver, renal glomerulus and tubules showed therapeutic effect with treatment of Phyllanthus emblica fruit extract 400mg/kg b.w and Terminalia arjuna bark extract 400mg/kg b.w. Conclusion: we observed the high fat diet induced structural and histological changes in the liver and renal tissue which was improved with Phyllanthus emblica fruit extract 400mg/kg compared with Terminalia arjuna bark.
Key words: High fat diet, renal glomerulus, Terminalia arjuna ,Phyllanthus emblica, Atorvastatin,
atherosclerosis.
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