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Research Article



Study the physiological effects of finasteride (prostacare) on some reproductive parameters in male rats.(Rattus- Rattus).

Assad H. Eisa AL-Edany.




Abstract

This study was conducted in the veterinary medicine college animal house and aimed to investigate the effect of finasteride (prostacare) on male reproductive system in albino male rats (Rattua-Rattus). Thirty six mature male rats with body weight 200-210 g and age 8 weeks of were randomly divided into three groups (12 animal each group). The first group was considered as control group and adminstreted orally normal salin (9%N.S)during the experimental 30 days , the second group was administrated finasteride(0.016mg) during the experimental(30)days.and the third group was administrated finasteride(0.032mg) during the experimental 30 days. The results showed a significant decrease in the sperm count ,sperm motility ,live sperm and increase in dead sperm percentage as well as a significant decrease in the level of reproductive hormones (testosterone, LH and FSH) in treated group with finasteride compared with control group , from this study it was concluded that the finasteride has sever side effect on fertility in albino male rats (Rattus-Rattus).

Key words: finasteride-sperm-fsh –LH






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