Adult Onset Still's Disease (AOSD) is a rare systemic inflammatory idiopathic disease that presents as a Fever of Unknown Origin (FUO) (in 5-10% of patients) accompanied by systemic manifestations. We report an interesting case of a 38-year-old Male Indian resident who presented with a fever of unknown origin (FUO) along with skin rash, sore throat, and arthralgia accompanied by systemic manifestations. After extensive workup, we ruled out potential differential diagnosis and a diagnosis of AOSD was suspected due to his clinical presentation and fulfilment of Yamaguchi and Fautrel criteria. This case report discusses the case history, clinical manifestations, diagnostic workups, and differential diagnoses.
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