Abstract

Aim: The aim of this study is to evaluate the possible beneficial effects of hyperoside (HYP) in the mitigation of torsion detorsion (TD)-induced testicular oxidative damage.
Materials and Methods: For this purpose, Wistar Albino rats were grouped (n=6 in each group) as sham, TD and TD+HYP groups. HYP was administered at 50 mg/kg dose p.o for 1 week. Torsion was created by twisting the spermatic cord clockwise by 720 degrees. The detorsion model was made by restoring the spermatic cord. Tissue oxidative and antioxidative stress parameters were measured according to biochemical methods to evaluate oxidative damage in testis.
Results: In particular, the oxidative stress parameters we measured were found to be significantly increased compared to the sham group in TD group depending on the TD model, but showed a significant decrease depending on the HYP treatment (p

Key words: Hyperoside; testis; torsion detorsion; oxidative stress