Cognitive functions: is there a role for vitamin D?
Mansuor Ahmed Alanazi, Ammar Ali Alabdullatif, Khadijah Nasr Aldeen Dhafer, Reem Nuri Alhasani, Abdullah Hassan Masoud Ghazwani, Eyad Omar Jalal, Maryam Abdullah Mossa Tohary, Naif Rashed Altuwaijri, Safeyah Mohammed Jarradi Al-ghubayshi.
Abstract
Vitamin D is an important nutrient required for many functions of the human body including metabolism of calcium and phosphorus, and thus playing a significant role in maintenance of bone integrity. Vitamin D plays important roles in multiple systems of the human body including the skeletal, cardiovascular, renal, hepatic, endocrine, and other systems. The main role of vitamin D in regulating bone integrity by maintaining calcium and phosphorus homeostasis is well-established. Several studies including both cohort models and cross-sectional models have reported significant correlation between low levels of vitamin D and reduced cognitive functionality. It has been suggested that the mechanisms involved in neuro-protection, calcium influx regulation and homeostasis, anti-inflammatory signaling, reduction of oxidative stress, neurotransmitter secretion, and neuro-vascularization may encompass the regulatory role of vitamin D in modulation of cognitive functions.
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