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Review Article

Transferosomes: Unique vesicular carriers for effective transdermal delivery

Rakesh Pahwa, Shweta Pal, Kamal Saroha, Parul Waliyan, Manish Kumar.

The utilization of vesicular carriers has recently emerged as a promising strategy to reduce the hindrance associated with the stratum corneum. Transferosomes are also recognized as ultradeformable lipids and elastic liposomes attract tremendous attention toward dermal delivery. They are predominantly used to treat various incidences of chronic skin disorders and also convenient for targeted as well as controlled delivery to manage patient compliance. These self-assembled nanocarriers are capable of molding themselves according to the pore size of the stratum corneum. Transferosomes may consist of edge activators (specialized surfactants), phospholipids, buffering agent, etc. The effect of edge activators and their concentration confers a desirable elasticity to assembled vesicles. Elastic liposomes are capable of optimizing the solubilization of the drug, effective drug loading capability, and permeability of therapeutic molecules. Transferosomes as nanocarriers exhibit advanced reflections and a versatile platform for successful transdermal applications. These unique nanocarriers also exhibit superior elasticity as well as penetration performance. These systems are considered secure with efficient delivery strategies for pharmaceutically as well as cosmeceutically active chemical moieties. Recent scientific observations indicating the importance of ultradeformable liposomes have shown reproducible and efficient permeation of active drugs. This manuscript covers the current research advancements along with informative reports addressing the important issues and usefulness of prospective transferosomes with a better bioavailability profile.

Key words: Transdermal delivery, Ultradeformable vesicles, Transferosomes, Self assembled, Improved skin permeation, Enhanced bioavailability.

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