The current study was carried out to isolate and identify marine fungi from the coastal region of Mumbai and assess their antibacterial potential. Aspergillus fumigatus, Histoplasma capsulatum, Cladosporium cladosporioides, Cladosporium pseudocladosporioides, Trichophyton rubrum, Penicillium chrysogenum, Alternaria alternate, Neoscytalidium dimidiatum and Aspergillus terreus were isolated and identified. The metabolite extraction was carried out by broth fermentation and extraction of dry mycelium using organic solvents like chloroform, ethyl acetate, and ethanol. Antibacterial potential of fungal metabolites was assessed by well diffusion method. Different concentrations (2–150 μg/ml) of extracts of broth and dry mycelia were tested against organisms like Escherichia coli, Enterococcus faecalis, Enterococcus faecium, Klebsiella pneumonia, Bacillus subtilis, and Staphylococcus aureus. Results revealed that chloroform and ethanolic extracts (2 μg/ml) from C. cladosporioides broth fermentation exhibit 100% growth inhibition of test organisms. Mycelium ethanolic extract of A. fumigatus, ethyl acetate extract of C. cladosporioides and chloroform extract of C. pseudocladosporioides exhibited maximum (100%) growth inhibition against all test organisms at 2 μg/ml. The study confirms the antibacterial potential of fungal metabolites and therefore paves a way for further identification of the active principles.
Key words: Marine Fungi, Fungal Metabolites, Antibacterial Potential, Mumbai, Bioactivity
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