Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Research

Role of vagus nerve in algogen-induced vasosensory reflex responses in anesthetized rats

Sanjeev K. Singh.

Background: It has been shown by various workers that intra-arterial (i.a.) instillation of algogens produced reflex cardiorespiratory (CVR) changes in anesthetized rats, substantiating the role of medium sized peripheral blood vessels in regulation of CVR system.

Aim and Objective: The aim of this study was to understand the role of vagus nerve in algogen- induced vasosensory reflex responses altering CVR parameters.

Material and Methods: Femoral artery was cannulated retrogradely and was utilized for the instillation of saline/bradykinin and recording of blood pressure (BP), using a double-ported 24G cannula. BP, respiration and electrocardiogram were recorded for 30 min after instillation of bradykinin with or without vagotomy. Bradykinin (1 μM) was used as an algogen for the elicitation of vasosensory reflex responses altering CVR parameters.

Results: Instillation (i.a.) of bradykinin produced immediate (5–8 s) hypotensive (40% of initial), bradycardiac (17% of initial), tachypnoeic (45% of initial), and hyperventilatory (96% of initial) responses. In the vagotomized rats, bradykinin-induced hypotensive (18% of initial), bradycardiac (1% of initial), tachypnoeic (5% of initial), and hyperventilatory (10% of initial) responses attenuated significantly.

Conclusion: Pre-treatment with bilateral vagotomy significantly attenuated the mean arterial pressure, heart rate, respiratory frequency and respiratory minute volume responses indicating the role of vagus in producing these responses.

Key words: Nociception; Vasosensory Reflexes; Bradykinin; Vanilloid Receptor 1; Cardiorespiratory Changes

Similar Articles

Epsin 3 potentiates the NF‑κB signaling pathway to regulate apoptosis in breast cancer.
Wu Q, Li Q, Zhu W, Zhang X, Li H
Molecular medicine reports. 2022; 25(1):

Dendritic spine density changes and homeostatic synaptic scaling: a meta-analysis of animal studies.
Moulin TC, Rayêe D, Schiöth HB
Neural regeneration research. 2022; 17(1): 20-24

Knockdown of lncRNA NEAT1 suppresses proliferation and migration, and induces apoptosis of cervical cancer cells by regulating the miR‑377/FGFR1 axis.
Geng F, Jia WC, Li T, Li N, Wei W
Molecular medicine reports. 2022; 25(1):

Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes.
Evrard M, Wynne-Jones E, Peng C, Kato Y, Christo SN, Fonseca R, Park SL, Burn TN, Osman M, Devi S, Chun J, Mueller SN, Kannourakis G, Berzins SP, Pellicci DG, Heath WR, Jameson SC, Mackay LK
The Journal of experimental medicine. 2022; 219(1):

Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity.
Ferrari F, Moretti A, Villa RF
Neural regeneration research. 2022; 17(2): 292-299

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.

ScopeMed Web Sites