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Pharmacokinetics of Cefquinome on Single Intramuscular Administration in Osmanabadi Goats by Microbiological Assay Technique

Matsygandha Kishanrao Patil, Arju Parju Somkuwar, Prafullakumar Vasantrao Patil.


Abstract

Experiment was performed on six healthy Osmanabadi goats of either sex having age to study the different pharmacokinetic parameters after single intramuscular administration @ 2 mg/kg body weight by microbiological assay technique. The peak serum concentration, absorption half life, distribution half life, elimination half life, volume of distribution, total body clearance, AUC, AUMC, MRT and bioavailability values found were 1.77 ± 0.113 mcg/ml, 0.23 ± 0.03h, 0.29 ± 0.04 h, 2.69 ± 0.07h, 1.89 ± 0.18L/kg (Vd(B)) and 2.01± 0.24 L/kg (Vdss), 0.50 ± 0.05 L/kg.h-1, 4.17 ±0.34 µg/ml.hr, 16.50 ±1.15 µg/ml.hr2, 3.99 ± 0.14 h and 100 % respectively. It may be concluded that the elimination half life of cefquinome was 2.54 h in goats indicating the repeating of doses at 12 to 15 h intervals in goats. The loading dose would be double than the maintenance dose of cefquinome after intramuscular administration.

Key words: Cefquinome, Intramuscular, Microbiological Assay Technique, Osmanabadi Goats, Pharmacokinetics






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