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Original Article

JCDR. 2015; 6(4): 176-178

Evaluation of Association between CRP Levels in Chronic Periodontitis patients and Chronic Periodontitis with Cardiovascular Diseases

Kundoor Vinay Kumar Reddy, Rashmi, Roja Ramani Kinnera, Kotya Naik Maloth,Kesidi Sunitha.


Background: C-reactive protein (CRP) levels increases to hundreds of
mg/L within hours following infection. Studies have shown that serum CRP
levels were elevated in periodontal disease. Numerous cross-sectional
studies have suggested that chronic periodontitis is a risk factor for cardiovascular
diseases (CVD). There is evidence that periodontitis and cardiovascular
diseases are linked by inflammatory factors including C‑reactive protein.
The purpose of the study was to investigate the levels of CRP as a marker
of inflammatory host response in the serum of chronic periodontitis
patients and in patients with CVD. Materials and Methods: Study population
included 75 patients; both male and female above 40 years of age were
included for the study. Based on clinical (probing depth (PD) ≥5 mm) and
radiolographical findings (bone loss more than 5mm from CEJ (cementoenamel
junction) and presence or absence of CVD. The study population
were divided into three groups of 25 each, Group I: Chronic periodontitis
patients with CVD, Group II: Chronic periodontitis patients without CVD
and Group III: Control (without chronic periodontitis and CVD). The control
group had PD ≤ 3 mm and no CVD. Venous blood was collected from the
patients and C‑reactive protein levels were analyzed by latex slide agglutination
method using commercially available kit with lower detection limit
of 10 mg/L. Results: On comparison, CRP values showed significant difference
from Group I to III. CRP level was highly significant in Group I when
compared with Group II and Group III. Conclusion: From this study we can
conclude that chronic periodontitis patients, with increased CRP levels are
more prone to CVD.

Key words: Periodontitis, C-reactive protein, Cardiovascular disease, Reactant proteins, Atherosclerosis, Inflammatory cytokines.

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