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Original Article

. 2012; 3(4): 290-295


QT Interval prolongation and dispersion: Epidemiology and clinical correlates in subjects with newly diagnosed systemic hypertension in Nigeria

Adeseye A. Akintunde, Adebayo T. Oyedeji, Oluranti B. Familoni, Olugbenga E. Ayodele, Oladimeji G. Opadijo.

Abstract
Background: The use of easily obtainable clinical and laboratory parameters to identify hypertensive patients with increased cardiovascular risk in resource limited settings cannot be overemphasized. Prolongation of QT intervals and increased dispersion has been associated with increased risk of cardiovascular death. The study aimed at describing the epidemiology of QT interval abnormalities among newly diagnosed hypertensive subjects and associated clinical correlates. Materials and Methods: One hundred and forty newly diagnosed hypertensive subjects and 70 controls were used for this study. Clinical and sociodemographic characteristics were obtained. Twelve lead resting electrocardiography, QT dispersion, heart rate corrected minimum and maximum QT intervals were determined manually. Increased QTcmax was defined at QTcmax >440msec. QT parameters were compared between various groups. SPSS 16.0 was used for data analysis. Results: The hypertensive subjects were well matched in age and gender distribution with controls. QTmax and QTcmax were significantly higher among hypertensive subjects than controls (379.745.1 vs. 356.735.6, 447.5 49.0 vs. 414.5 34.7 ms, respectively, P

Key words: Clinical correlates, hypertension, Nigeria, QT dispersion, QT prolongation


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