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Original Article

JCDR. 2011; 2(3): 172-176

Reduced nitrate level in individuals with hypertension and diabetes

Shiekh Gazalla Ayub, Taha Ayub, Saquib Naveed Khan, Rubiya Dar, Khurshid Iqbal Andrabi.


Background: Nitric oxide (NO) turnover is vital for proper endothelial function to maintain a healthy vascular
system. Various risk factors responsible for hypertension and diabetes may disrupt this homeostasis, leading to
decreased bioavailability and/or bioactivity of NO, which potentiates endothelial dysfunction. Plasma NO is a
useful indicator of NO homeostasis and vascular endothelial function. Since endothelial function plays a key
role in the development and progression of diseases like diabetes and hypertension, we sought to investigate
the NO profile in patients having diabetes and hypertension and determine the relationship of NO turnover
with the disease. Materials and Methods: For this purpose, three groups were studied for the NO production.
The first group consisted of 74 hypertensive patients, the second group consisted of 72 diabetic patients and
the third group consisted of 60 healthy controls. Nitrate synthase activity was evaluated by measuring nitrate
level using an automated sample injector connected to an automated NO detector – Ion liquid chromatograph.
Results: The plasma concentration of NO was found to be significantly lower in both essential hypertensive
patients and diabetic patients without complications as compared to the healthy controls (P < 0.05). Conclusion:
This data confirms that different factors like hyperglycemia and blood pressure are seen to have immense
influence on NO production.

Key words: Diabetes, hypertension, nitric oxide

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