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Original Article

pnr. 2021; 12(2): 1-5

White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor ‎Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats

Aseel J Ali, Huda G Hameed, Ihab A Ahmad, Marwan S Al-Nimer.


Topical application of dimethybenz[a]anthracene (DMBA) on the oral mucosa is an experimental ‎model of tumorigenesis that widely used for assessing of chemopreventive substances. Camellia ‎sinensis contains polyphenols and flavonoids that act as antioxidants and anticancer. White tea ‎infusion contains a lower concentration of polyphenols compared with green or red tea. This ‎study aimed to investigate the effect of using white tea infusion on the DMBA-induced oral ‎tumor by assessing biomarkers related to the development of oral tumor. DMBA (0.5% w/v ‎dissolved in acetone) was applied topically to the oral mucosa, five times weekly for twelve ‎weeks followed by tape water infusion or white tea infusion (10% w/v) for another eight weeks. ‎Serum biomarkers related to the tumorigenesis including, C-reactive protein (CRP), tumor ‎necrosis factor (TNF-α), epidermal growth factor receptor (EGFR), and carcinoembryonic ‎antigen (CEA) were determined. Serum level of CEA and the ratio of EGFR-to TNF-α were ‎significantly increased in rats treated with white tea infusion compared with rats treated with ‎tape water. Thus, white tea infusion at 10%w/v for 8 weeks provokes oral tumor induced by a ‎topical application of DMBA by the evidence of a significantly increased the values of ‎biomarkers related to tumorigenesis.‎

Key words: dimethybenz[a]anthracene, white tea, oral mucosa, tumorigenesis biomarkers

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