Objective: Neuropathic pain, which is chronic pain, can affect the quality of life individuals. It can cause psychiatric problems such as depression and anxiety. Mirtazapine is an atypical antidepressant which has both noradrenergic and specific serotonergic receptor antagonism and shown to have anxiolytic, anti-emetic and appetite stimulating effects along with its antidepressant effect. It is generally tolerated better and has a different way of action when compared with other antidepressants used to treat neuropathic pain. Thus, we aimed to investigate its potential preventive effect in neuropathic pain in nerve ligated rat model. Methods: Forty rats were divided into five groups including the sham, the sciatic nerve ligation group and the third, fourth and fifth sciatic nerve ligation+mirtazepine groups which were treated with 5 mg, 10 mg and 15 mg/day mirtazapine, respectively. The tail flick and hot plate tests were performed on all the five groups, and the latency times were measured. Morphine was used as a positive control agent. Results: Administration of mirtazapine, restored both tail flick and hot plate latencies in a dose-dependent manner, meaning that mirtazapine is effective in treating neuropathic pain in this animal model. Mirta-zapine also restored the antinociceptive response to morphine significantly. Discussion: Mirtazapine appears to be good candidate for both neuropathic pain treatment and accompanying psychiatric condition such as depression and anxiety with its dual effect on neurotransmitters.
Article Language: Turkish English Similar Articles
Medicine in motion: Opportunities, challenges and data analytics-based solutions for traditional medicine integration into western medical practice.
Jansen C, Baker JD, Kodaira E, Ang L, Bacani AJ, Aldan JT, Shimoda LMN, Salameh M, Small-Howard AL, Stokes AJ, Turner H, Adra CN
Journal of ethnopharmacology. 2021; 267(): 113477
Effect of Lavender Aromatherapy On Arteriovenous Fistula Puncture Pain and the Level of State and Trait Anxiety in Hemodialysis Patients: A Randomized Controlled Trial.
Åahin S, TokgÃ¶z B, Demir G
Pain management nursing : official journal of the American Society of Pain Management Nurses. 2021; ():
Understanding the immune drivers of food-induced abdominal pain.
Nature reviews. Gastroenterology & hepatology. 2021; ():
Efficacy, safety, and tolerability of sublingual fentanyl orally disintegrating tablet in the treatment of breakthrough cancer pain: a randomized, double-blind, placebo-controlled study.
Hashemi M, Zali A, Golmakani E, Delshad MH, Shadnoush M, Akbari ME
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2021; ():
The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain: An 8-week randomized double-blind placebo-controlled trial.
Wang SJ, Wang YH, Huang LC
Medicine. 2021; 100(5): e24252
A rare case of right shoulder pain.
Bansari A, Radhakrishnan NS, Kattan JN
BMJ case reports. 2021; 14(2):
Quality of life in patients with breakthrough cancer pain in radiation oncology departments in Spain: the CAVIDIOR study.
Hernanz de Lucas R, NuÃ±ez FernÃ¡ndez M, GÃ³mez-CaamaÃ±o A, Morera LÃ³pez R, Fortes de la Torre I, de la Torre TomÃ¡s A, MuÃ±oz-GarzÃ³n V, LÃ³pez Bermudo C, MaÃ±as Rueda A
Future oncology (London, England). 2021; 17(8): 943-954
Cross-sectional study of psychosocial and pain-related variables among patients with chronic pain during a time of social distancing imposed by the coronavirus disease 2019 pandemic.
Hruschak V, Flowers KM, Azizoddin DR, Jamison RN, Edwards RR, Schreiber KL
Pain. 2021; 162(2): 619-629