Home|Journals|Articles by Year

Directory for Medical Articles

Original Article

pnr. 2021; 12(1): 48-53

Negative Pharmacokinetics Evaluation of Liquorice and Pomegranate Juices on Potential of Salbutamol in Rats

Wael Abu Dayyih, Riad Awad, Mohammed Hamad.


Beverages or food may alter the pharmacokinetic parameters and pharmacodynamics of drugs-substances’ active pharmaceutical ingredients which may cause adverse circumstances. Salbutamol is widely indicated to prevent asthma and acute/chronic obstructive pulmonary disorders. Liquorice and/or Pomegranate are prescribed to support cough and asthma management. Nonetheless, an interaction thereafter with a Salbutamol pharmacokinetics was not investigated yet. Thus, the aim of this research is to evaluate the effect of Liquorice and/or Pomegranate on Salbutamol pharmacokinetic-parameters in animals (rats).

Methods and Materials:
A Chromatography method of (HPLC) was carried out. Partially validated after a development profitably conformed to the European Medical Agency’s guidelines to measure Salbutamol in rat serum. Liquorice and/or Pomegranate juices were given to rats for three days and, an hour sooner than Salbutamol (5.0 mg/kg), it was administered as an oral solution. Blood samples were collected at scheduled intervals, then handled and investigated by HPLC methodology.

The linearity of the calibration curve was over 98%. The intra-day and the inter-day accuracy values of Salbutamol were (97.93%-105.18%), and (98.67%-105.91%), respectively. While the intra- and inter-day precision values were equal to or less than 3.178% and 3.653%, respectively. In addition, no significant change was seen in the pharmacokinetic parameters of Salbutamol when administered to rats that were given either pomegranate or Liquorice juice.

It was established that the given Liquorice or pomegranate juices with the above-mentioned orally administrated Salbutamol solution, did not result in a significant parameter in the pharmacokinetic interaction.

Key words: Salbutamol, Liquorice, Pharmacokinetics Parameters, Pomegranate, Preclinical, Negative

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.