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Review Article

SRP. 2011; 2(2): 79-85

Particle Size Enlargement: Making and Understanding of the Behavior of Powder (Particle) System

Kale VV, Gadekar S, Ittadwar AM.

Particle size enlargement is the process of transforming fine particles into larger particles by the
introduction of external forces, and is a value-added step in many processes involving powdered
materials. There are many different reasons to enlarge particle size, including increased flowability
and improved product shape and appearance. With the multitude of options available to achieve
enlarged particle product, it can be difficult to narrow down the best method for the desired
application. The main factor in selecting the right kind of method is to specify the type of end
product required. In the pharmaceutical industry in particular, uniform flow of solid mixtures is one
of the most important considerations in solid dosage manufacture. The particle size distribution,
shape, hardness, and moisture content of the powder particles govern its flow and compactibility
property. This article outlines making of enlarged particles and understanding their behavior.

Key words: Compressibility Flowability Particle shape Particle size enlargement

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