Elevation of fasting plasma triglycerides above the normal level (150 mg/dL) is an indication of
hypertriglyceridemia (borderline high, 150–199 mg/dL; high, 200-499 mg/dL; very high, above
500 mg/dL). A plethora of experimental and clinical studies evidenced a perceptible association
between hypertriglyceridemia and cardiovascular disease. Hypertriglyceridmia could lead to
endothelial dysfunction, atherosclerosis, hypertension, and ischemic heart disease. In addition,
studies have demonstrated the myocardial susceptibility to ischemia-reperfusion injury in the
hypertriglyceridemic condition. Importantly, hypertriglyceridemia alone may cause cardiovascular
abnormalities like atherosclerosis even in absence of hypercholesterolemia. It is worth-mentioning
that a pharmacological reduction in triglyceride levels diminishes the cardiovascular disease
pathogenesis. It is a subject of contemporary interest to detail whether hypertriglyceridemia a
key detrimental factor or an associative triggering factor for cardiovascular abnormalities. This
review will discuss the potential role of hypertriglyceridemia in the pathogenesis of cardiovascular
coronary artery disease,
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