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Principles and Practice of Clinical Research - Study Design

SRP. 2013; 4(1): 26-30

Invasomes-novel Vesicular Carriers for Enhanced Skin Permeation

P. K. Lakshmi, B. Kalpana, D. Prasanthi.

Invasomes are the liposomal vesicles embodying small amounts of ethanol and terpenes or
terpene mixtures, which act as potential carriers with increased skin penetration. Invasomes
have higher penetration rate through the skin as compared to liposomes and ethosomes.
Invasomes provide a number of advantages including improving the drug’s efficacy, enhancing
patient compliance and comfort. This article reviews various aspects of invasomes including
their preparation, characterization, potential advantages in drug delivery. Enhanced delivery
of drugs through the skin and cellular membranes by means of an invasomal carrier opens
numerous challenges and opportunities for research and future development of novel improved

Key words: Invasomes, permeation enhancement, transdermal, vesicular drug delivery

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