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Review Article

SRP. 2013; 4(1): 20-25

Smart Drug Delivery Systems as Game Changers in Therapeutics

Amita Bhandari, Anantha N. Naik, Shaila Lewis.

Smart Drug Delivery Systems (SDDS) have emerged as panacea for many clinically useful drugs
weighed down with toxicity. The discovery of Amphotericin B as a liposome has raised hopes
and directed mammoth efforts in SDDS. The concept of manipulation of toxicity has given rise
to additional significant approaches like targeting and use of physico-chemical approaches.
Currently the spectrum of SDDS comprises of targeting liposomes, drug loaded biodegradable
microspheres, stimuli responsive drug polymer conjugates, smart hydrogels, polymeric micellar
particles, intelligent lipoprotein carriers, and nano carriers. There is a wealth of knowledge
accumulated worldwide in the area of SDDS, which can be extremely beneficial to industry as
well as practitioners of health care. In this article an overview of developments are reviewed.

Key words: Liposomes, smart drug delivery systems, stimuli responsive

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