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Review Article

SRP. 2017; 8(1): 76-79


Gold (III) Complexes as Breast Cancer Drug

Firas Hassan, Salam Abd AlQadeem Mohammed, Anil Philip, Ayah Abdul Hameed, Emad Yousif.

Abstract
Transition metals represent the d block element which includes groups 3-12 on the periodic table. Their d shells are in a process of filling. This property of these kinds of metals realized the foundation of coordination structures. Some of new gold (III) compounds have been prepared that are enough consistent under physiological conditions and are promising contender for pharmacological testing as cytotoxic and antitumor administrators. In vitro pharmacological studies point out that some of these novel gold (III) structures are astoundingly cytotoxic toward refined human tumor cell lines. Preliminary results on legitimate to DNA in vitro were exhibited, raising that the affiliations were generally slight. A few of Au (III) mixes with multi-dentate ligands such asen (ethylendiamine), dien (diethylendiamine) and sticky (N-benzyl-N, N-dimethylamine) have been seen to be dynamic against human tumor cell lines.

Key words: Gold (III) complex, Breast cancer drug, Anti-proliferative, Multi-dentate ligand, Antitumor, Auranofin.



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