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Original Article

pnr. 2021; 12(2): 18-23

The value of lisnopril in managing impaired fertility in experimental rats following alloxan induced hyperglycemia

Mohammed j Manna, Murtadha S Jabur.


Background: It has been shown that the chronic metabolic derangement accompanying long standing hyperglycemia, both in experimental animals and man, may alter fertility in males. This work investigate the role of lisnopril in improving fertility parameters .
Aim of the study: To evaluate the role of lisnopril with respect to fertility parameters in experimentally induced hyperglycemia in rats.
Materials and methods: Three groups of rats were subjected to alloxan induced hyperglycemia, placebo treatment (control group), and alloxan and lisnopril treatment (study group). Each group included 10 animals. Sperm parameters, hormonal levels, markers of oxidative stress and histophotometry were done .
Results: Sperm parameters in the form of sperm count, normal morphology, motility and number of dead sperms were significantly altered following alloxan induced hyperglycemia (P < 0.001). The administration of lisnopril showed significant improvement in sperm parameters (P

Key words: Alloxan, Hyperglycemia, lisnopril, male infertility

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