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Original Article

pnr. 2014; 5(1): 19-21


Lack of diuretic activity of water extract of leaves of Pongamia pinnata L. in rats

SA Deraniyagala, WD Ratnasooriya, S Priyadharshini, TRK Perera.


Abstract

Objective : To assess the diuretic potential of water extract (WE) of leaves of Pongamia pinnata L. Materials and Methods : Different doses (500, 1000, 1500, and 3000 mg/kg) of WE of the leaves of P. pinnata or vehicle or furosemide, reference drug was orally administered to hydrated rats (n = 6/group) and their cumulative urine output was monitored at hourly intervals for 6 h. Result : The WE of P. pinnata does not possess significant (P > 0.05) diuretic activity. Conclusion : The WE of the leaves of P. pinnata did not possess diuretic activity in rats as was claimed in traditional and folkloric medicine.

Key words: Diuresis, diuretic, Pongamia pinnata, traditional medicine






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