Introduction: Monoammonium glycyrrhizinate (MAG) is used as a sweetener and also as a flavoring agent to enhance the flavor of dairy products, confectioneries, baked foods and beverages. It is used in cough drops, cough syrups and cosmetics. It is reported to have antioxidant, antitussive and antiviral activities. Materials and Methods: The in-vitro α - amylase inhibitory activity was performed using 3,5-dinitrosalicylic acid assay. Different concentrations (1 μg/ml, 3 μg/ml, 5 μg/ml, 10 μg/ml, 30 μg/ml and 50 μg/ml) of MAG were analyzed for the α - amylase inhibitory potential. Results: The results of this study revealed that MAG lacks α - amylase inhibitory potential. Conclusion: Documentation of pharmacological activities of phytochemicals, which have either positive or negative outcome, is required to create a database for phytopharmacological research. The result of this study can serve as one of the components of phytochemical research database.
Key words: add-on therapy, enzyme inhibitors, Glycyrrhiza glabra, monoammonium glycyrrhizinate