Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Article

pnr. 2020; 11(1): 23-29


Influence of polylactic acid and polycaprolactone on dissolution characteristics of ansamycin-loaded polymeric nanoparticles: An unsatisfied attempt for drug release profile

Keerthi GS Nair, Ramaiyan Velmurugan, Sathesh Kumar Sukumaran.

Abstract
Objectives: The purpose of the current examination was to establish a polymeric nanoparticle (NP) to supply Ansamycin to the central nervous system by improving blood–brain barrier permeability for bacterial meningitis, by emulsification solvent diffusion technique with numerous hydrophilic carriers. Materials and Methods: The polymeric NPs were prepared by emulsification solvent diffusion technique making use of Polylactic acid (PLA) as well as Polycaprolactone (PCL). Physical mixtures of drug with above-mentioned polymers were likewise prepared. The formulations were examined for Fourier-transform infrared spectroscopy and as well as differential scanning calorimetry (DSC), particle size, and also in vitro dissolution. Similarity factor (f2) was determined for the comparison between dissolution of pure drug and also drug polymer physical mixtures with NPs. Results: Phase solubility researches showed linear increase in the drug solubility with rise in carrier concentration. In vitro release studies disclosed that dissolution quality of Ansamycin was not satisfactory with PLA and also PCL for the release quality of the Ansamycin from the formulation. Nanoformulation of Ansamycin with PLA and also PCL displayed inadequaterate and extent of dissolution. Optimized batches of nano formulations of both the carriers were identified by the Fourier-transform infrared spectroscopy and also DSC evaluation, which suggested existence of interactions between ansamycin and carriers. Conclusions: PLA as well as PCL are not the appropriate polymers to serve as a carrier to deliver Ansamcyin.

Key words: Ansamycin, in-vitro drug release, nanoparticles, polycaprolactone, polylactic acid


Full-text options

Full-text Article




Advertisement
American Journal of Diagnostic Imaging

SUBMIT YOUR ARTICLE NOW




ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.