Introduction: hepatitis C virus (HCV) is most common viral infection as result of RNA flavivirus. Sudden features and symptoms of infection by this virus is unusual and person ignorant the infection and become aware when signs and symptoms appear screened for other reasons or when they develop chronic liver disease.
Method: This prospective observational comparative study included 408 patients with ESRD on hemodialysis, 263 (64.46%) were female and 145 (35.53%) were male, their age ranged from 15 to 78 years (44.39 ± 15.06 S.D.). Results: Among the 408 CKD patients on hemodialysis; Almost two-third were female, 263 (64.46%) and 145 (35.53%) were males. Their age range was 14-79 years (39.55±12). Nearly one third (134/408, 32.8%) of the study subjects were anti-HCV IgG antibody positive ,85 (20.8%) were female, and 49 (12%) were males, age ranged from 14-57 years (mean ± SD 37.2±9 years) with variable frequencies among the three centers as following 41/129 (31.72%),31/89 (34.83%),62/190 (32.63%). There was no significant difference for age, between both groups A1 and A2 P- value more than 0.05. Nevertheless, mean of HB, hematocrit, count of platelet, aspartate transaminase level (AST), alanine transaminase level (ALT), prothrombin time (PT), and partial thromboplastin time (PTT) were higher in A1 than A2 and were significant.
Conclusion: decrease of factors that depend on releasing of vitamin K occur when there is liver cirrhosis as the following: decrease hepatic production besides decrease bile salts absorption that responsible for absorption of factors in need of vitamin K, occur in cholestasis liver illnesses. The PT test evaluates the function of coagulation elements in usual way of coagulation flow that include; Fibrinogen (I), Prothrombin (II), V, VII as well as X.
Arteriovenous fistula, hemostatic, hepatitis C virus.