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Original Article

. 2017; 8(4): 157-159

Papaverine on Internal Mammary Artery Flow- Comparitive Study of Intraluminal versus Topical

Pangi Manish, Garg Arun, Sreedhar Kumsi.

Background: Coronary artery bypass grafting (CABG) is the commonest method for surgical revascularisation and Left
Internal Mammary artery (LIMA) is the conduit of choice. However it may develop vasospasm during harvesting. Vasodilators
like Papaverine have been proposed to relieve vasospasm and hence increase blood flow. However the optimal
method of papaverine application is not clear. In this study we have compared the effects of intraluminal versus topical
application of papaverine on LIMA flow. Methods: This was prospective randomized controlled trial of 60 patients. They
were divided into two groups: group 1 (n=30; intraluminal papaverine application) and group 2 (n=30; topical papaverine
application). LIMA was harvested, divided and the blood flow from distal cut end was measured under controlled
hemodynamics, before papaverine application and 5 min after papaverine application. Results: In group 1, the mean
blood flow was 61.073.1 ml/min before papaverine application and 119.63.72 ml/min after intraluminal instillation (p

Key words: CABG, Intraluminal, Internal mammary, OPCAB, Papaverine

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American Journal of Physiology, Biochemistry and Pharmacology


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