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Original Article

. 2017; 8(4): 151-156


Activation of Cardiac TNF-α in Altered Thyroid State-Induced Cardiometabolic Disorder

Ayodeji Folorunsho Ajayi, Roland Eghoghosoa Akhigbe, Lydia Oluwatoyin Ajayi.

Abstract
Background: It is a known fact that altered thyroid state is associated with cardiometabolic disturbances. Raised TNF-α
and lipid peroxidation have also been reported to be involved in the pathogenesis of cardiometabolic disorders. Aim: The
present study evaluates the effect of dysthyroidism on cardiac TNF-α and lipid peroxidation, and whether the effect is
estradiol-dependent. Methods: Male white New Zealand rabbits were randomized into three groups; control, carbimazole-
induced hypothyroidism, and levothyroxine-induced hyperthyroidism. Results: Dysthyroidism led to altered glucose
metabolism and dyslipidaemia with elevated LDL, TNF-α, and MDA. There was also decreased HDL, GSH, catalase, and
17β-estradiol. Serum electrolytes and hemorheological variables were not significantly affected. Conclusion: These findings
demonstrate that dysthyroidism-induced cardiometabolic disturbance is associated with elevated cardiac TNF-α and
oxidative stress via an estradiol-dependent mechanism.

Key words: Dysthyroidism, Lipid Peroxidation, TNF-α, Oxidative Stress, Cardiometabolic Disorder.


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