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Original Article

. 2014; 5(4): 15-21

Levels of thyroid hormone, ferritin and testosterone in Acute Myocardial Infarction (AMI) patients in north India

Atreyee Basu, Shashi Seth, Kanchan Arora, Nupur Bansal.

Background : Thyroid hormone plays a critical role in cardiomyocyte maturation and stress-related cellular responses
like AMI. The inhibition of thyroid hormone receptor alfa (TRĪ±) causes down regulation of this hormone in post-ischemic
myocardium. On the other hand, ferritin, an inflammatory marker; and testosterone, a hormone which alters lipid profile,
also play significant roles in pathogenesis of AMI. The objective of our study was to compare thyroid profile (total T3,
T4 and TSH), ferritin, Vitamin B-12, folic acid and testosterone in newly diagnosed male cases of AMI with age-matched
controls. We also contrasted these biochemical parameters between AMI subgroups with very low and low left ventricular
ejection fraction (LVEF). Methodology :A cross-sectional study was conducted from September, 2012 to February, 2013
at a tertiary care hospital of north India. Newly diagnosed male AMI patients with positive clinical and ECG findings,
and CPK MB > 25 U/L (spcetrophotometric method) and Troponin-I ultra > 2ng/ml (chemiimmunofluroscence method)
were enrolled as cases (n=43). Cases were further sub-classified into those with very low LVEF (

Key words: AMI, Thyroid hormone, Ferritin, Testosterone

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