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Original Research

RMJ. 2007; 32(2): 173-175


Comparison of Antiphospholipid Antibodies in Hypertensive with Normotensive Pregnant Women

Rezvanieh Salehi, Azin Alizadeh Asl, Mahasti Alizadeh, Manijheh Sayyahmelli, Rasoul Azarfarin.




Abstract

Objective: The aim of this study was to assess the association between the occurrence
of hypertension (HTN) in pregnancy and antiphospholipid antibodies.
Methods: We conducted a cross-sectional study of 100 pregnant women with their
first pregnancy induced HTN and no history of thrombosis, renal disease or systemic
autoimmune diseases. HTN was defined as blood pressure (BP) of 140/90 mmHg or
higher on two measurements with 6 hours apart. Control group comprised of
pregnant women without hypertension or proteinuria and without history of
thrombosis or systemic autoimmune disease. Antiphospholipid Antibodies
(Antiphospholipid IgG and IgM and anticardiolipin IgG and IgM) levels were
measured in both groups.
Results: There were significantly higher titer of Antiphospholipid IgG and
anticardiolipin IgG and IgM in case group (p

Key words: antiphospholipid antibodies, anticardiolipin antibodies, pregnancy, hypertension.






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