Objective: In this work, role of hypoxia in respiratory system on live and exited newborns (weight 250-3000 g.) which have died due to different reasons is studied. Methods: Response of tracheal rings in acetylcholine and histamine in different molar concentrations (10-4, 10-3, 10-2, 10-1 mol/dm3) was monitored. Study of the tracheal smooth musculature (TSM) tonus was performed in 12 tracheal preparations obtained from the newborns exited due to different reasons. Results: Based on the functional analysis of the isolated tracheal preparations, we have concluded that the cases born with lung atelectasis have caused significant response of TSM to Acetylcholine and Histamine (p > 0.01). In cases of control group, which has exited due to different reasons from lung inflammatory processes (e.g.: pneumonia, bronchopneumonia, cerebral hemorrhage), Acetylcholine and Histamine have also caused significant constriction of tracheal smooth musculature. Conclusion: Results suggest that exited cases with lung atelectasis (hypoxemia) and cases of lung inflammatory processes have significant constrictor action to Acetylcholine and Histamine in tracheobronchial system.
Key words: Trachea, Acetylcholine, Histamine.
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