Objective: This study aimed to investigate the vasorelaxation effect of nebivolol on vasospasm in the rabbit model of Subarachnoid Hemorrhage (SAH).
Material and Methods: Single-hemorrhage model in the rabbit SAH was employed. SAH was induced in animals by cisterna manga injection of 4 mL autologous blood. Thirty-two animals were categorized into four groups: 1) control group (no SAH), 2) SAH group, 3) SAH + solvent infused group and 4) SAH+ nebivolol treatment group.
Forty-Eight hours after SAH-induction, rabbits in group 3 and in 4 were received solvent or nebivolol, respectively. Nebivolol (0,073 mg/kg) was administered via the vertebral artery in 5 minutes. Digital subtraction angiography was performed at Forty-nine hour following SAH-induced groups. The diameters of basilar arteries in four groups were measured at three points, and the average of the measurements is accepted as a consecutive result.
Results: SAH-induced rats demonstrated severe vasospasm on day 2. Angiographic vasospasm was present in group 2 (SAH only), and in 3 (SAH plus solvent). Animals in group 4 (SAH plus nebivolol) and group 1 (control), respectively, demonstrated the largest diameters of basilar arteries. Animals treated with nebivolol has reached eighty-eight percent of the value in the control group 1. There was no statistical difference between the control group and SAH plus nebivolol treatment group (p>0.05). However, the difference was obtained between the groups SAH plus solvent and SAH plus nebivolol treatment (p
Key words: nebivolol; subarachnoid Hemorrhage; vasospasm; rabbit
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