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Original Article



Ichthyotoxic Principles against Zebrafish Embryos from the Indonesian Marine Sponge Neopetrosia chaliniformis

Novriyandi Hanif, Resi Ardianti, Peni Ahmadi, Andi Setiawan, Kusdiantoro Mohamad, Nicole J. de Voogd, Anggia Murni, Junichi Tanaka.




Abstract

A study on the extract of the Indonesian marine sponge Neopetrosia chaliniformis for the ichthyotoxicity and teratogenic effect against zebrafish embryos led to the identification of oxaquinolizidine alkaloids araguspongines C (1) and D (2). Their structure and conformation were determined on the basis of spectroscopic method and molecular modelling analysis.

Key words: Oxaquinolizidine, Alkaloid, Neopetrosia chaliniformis, NMR, Molecular Modelling






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