Purpose: This study aims to formulate and evaluate the characteristics and the skin penetration of green tea leaves extract loaded solid lipid nanoparticles (GT-SLN).
Methods: GT-SLN was prepared by solvent emulsification-evaporation method. The properties of SLN were characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), differential scanning calorimetry (DSC), and in vitro penetration studies were investigated with Franz diffusion cells.
Results: The GT-SLN1 presented spherical shape with an average particle size of 155.6 ± 10.04 nm; polydispersity index of 0.409 ± 0.05; zeta potential of -30.967 ± 1.29; entrapment efficiency of 81.124±0.443%. In vitro penetration study with Franz diffusion cell showed flux value from GT-SLN1 of 1.965±0.025 μg/cm2.hour and GT 0.261±0.005 μg/cm2.hour.
Conclusion: In vitro skin penetration study showed that solid lipid nanoparticles improved the penetration of epigallocatechin gallate (EGCG) through the stratum corneum.
Key words: solid lipid nanoparticle (SLN), Camellia sinensis, skin penetration, solvent emulsification, green tea, epigallocatechin gallate (EGCG)
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