The tubular ductal complexes consist of duct-like structures that have seen a low incidence and smaller number in the pancreas of azaserine-treated rats. These lesions are found more characteristically in carcinogen-treated hamsters or rats treated with different carcinogens. There is little known about histologic patterns of these lesions of azaserine/rat model. Since the dominant lesions in the pancreas of azaserine- treated rats appear to be derived from acinar cells, in the present study the presence of ductal complexes provides support for the view that such lesions result from the effect of azaserine and oleic acid on acinar cell rather than on ductal cells. The tubular ductal complexes occurrence appear to effect of oleic acid feeding, but no clear evidence. The significance of these finding remains unclear. [Journal of Turgut Özal Medical Center 2(2): 126-129,1995]
Key Words : Rat, azaserine, ductular complex, pancreas
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