Abstract

Diabetes mellitus is a significant public health problem worldwide. Oxidative stress plays a pivotal role in the pathogenesis of diabetes as it is one of the inevitable outcomes of the cellular process. The present study aims to investigate the putative antihyperglycemic, antihyperlipidemic and antioxidant efficacy of limonene and vitamin E compared with metformin, a standard drug for the therapy of diabetes. Diabetes was induced by a single intraperitoneal injection of 150 mg/kg of alloxan. There was a significant (P

Key words: D-limonene; vitamin E; erythropoiesis; β-cells; diabetes; rats